Biotage® Initiator+ SP Wave

Two Synthesizers in One

Biotage® Initiator+ SP Wave is a versatile microwave system for the synthesis of both peptides and organic compounds. It can be used as a standalone single channel microwave peptide synthesizer or easily converted to a high-end microwave synthesizer.

Benefits

Biotage® Initiator+ SP Wave is a versatile microwave system for the synthesis of both peptides and organic compounds. It can be used as a standalone single channel microwave peptide synthesizer or easily converted to a high-end microwave synthesizer

initiator-peptide
  

Peptide Mode

It is the ideal tool for the synthesis of peptides, peptidomimetics, PNA and for organic, medicinal, materials, nano and
polymer chemistry applications.
The instrument functions are controlled directly on the built in touch screen interface. Deprotection and washing steps are automated, while adding activated building blocks is performed manually. With this approach, intermediate reaction steps are easily monitored, and less equivalents can be added to reduce unnecessary waste of expensive reagents. Reactions are performed in disposable polypropylene reactor vials and mixing is achieved by vortex mixing.
This is a powerful development tool giving total control of the method development process using single or multi-step procedures.
 

Microwave Assisted Organic Synthesis Mode

When configured as a microwave synthesizer, the Initiator+ SP Wave is able to perform reactions at a temperature of 300 °C and 30 bar pressure and capable of processing up to eight reactions unattended. Reactions are performed in microwave glass vials and mixing is achieved by magnetic stirring.
The 8-position sample bed gives the user a compact automation solution to start scale-up process and library build-up. The 8-position system is useful in a multi-user environment or for queuing multiple reactions. Flexible
operation enables the use of both large and
small vials in combination at any time and in any order without manual intervention.



Specifications

SYSTEM REQUIREMENTS

Home
LOCATION     A laboratory fume hood with the capacity to handle leakage of solvents and provide suitable airflow to prevent the build-up of flammable vapors.

ambient temperature
AMBIENT TEMPERATURE      Operating Temperature: 18–32 °C Storage and transportation temperature: -25 °C to 60 °C

Humidity
HUMIDITY     20–95% at room temperature
 
Electrical Supply
ELECTRICAL SUPPLY     Europe: 220–240 V~, 50 Hz (5 A) US and Japan: 100–120 V~, 50/60 Hz (10 A)

Max. Power Consumed
MAX POWER CONSUMED     1100 VA
 
Weight
WEIGHT     33 kg (72.7 lbs)

Dimensions 3D
DIMENSIONS     Footprint (W x D x H): 400 mm x 500 mm x 685 mm (15.7″ x 19.7″ x 27.0″)

Ethernet LAN
PORTS     Ethernet LAN port. Complies with IEEE 802.3 (ANSI 8802-3). USB port. Complies with USB 3.0

Touch Screen
INTERFACES     On-board computer with 10.4” diagonal touch screen interface. Archiving/back-up is done via USB. Printing is done via LAN.

Certification
CERTIFICATES     CE, CSA certified

Vacuum
VACUUM PUMP     Minimum partial pressure: 100 mbar Minimum flow rate: 11 L/min

HEATING PROCESS
 
Temperature Span
TEMPERATURE RANGE     Peptide synthesis: 40°C to 100°C

Temperature Span
Organic synthesis:    40°C to 300°C

temperature increase
TEMPERATURE INCREASE     Typically 2–5 °C/sec depending on solvent and power applied

Pressure
PRESSURE RANGE     Peptide synthesis: Run at atmospheric pressure

Pressure
Organic synthesis:    0 to 30 bar (3 MPa; 435 PSI)


power range
POWER RANGE     Peptide synthesis: 0 to 120 W from magnetron at 2.45 GHz


power range
Organic synthesis:     0 to 400 W from magnetron at 2.45 GHz


Fraction Volume
REACTOR VIAL SIZES     Peptide synthesis: 2 mL, 5 mL and 10 mL


Fraction Volume
Organic synthesis:    0.2–0.5 mL, 0.5–2.0 mL, 2.0–5.0 mL and 10–20 mL
AGITATION     Peptide synthesis: Vortex unit (500 to 1300 rpm)
Organic synthesis: Magnetic stirrer (300 to 900 rpm)

Fraction Volume
REACTION VOLUMES     Peptide synthesis: 2 mL reactor vial: 0.8–1.1 mL – 5 mL reactor vial: 1.6–3.2 mL – 10 mL reactor vial: 3.2–6.4 mL

Fraction Volume
Organic synthesis:    0.2 to 20 mL in microwave reaction vials

Gas Air
INERT GAS (OPTIONAL)     Approx. 2 L/min (0.07 cubic feet/min); 0.5 bar (0.05 MPa; 7.25 PSI)


LIQUID HANDLING
 
Format
SYRINGE PUMP     Digital single syringe pump, 11 mL with sample loop

Flow Rate
FLOW RATE     2–50 mL/min

V-10 vial
REAGENT BOTTLE RACK     3 x 100 mL

Solvent
SYSTEM SOLVENT     1 x 2000 mL