Syro I

Fully Automated Parallel Peptide Synthesizer

Syro I is a fully automated multi-channel peptide synthesizer equipped with a one arm pipetting robot. The standard system is configured with one reactor block (24 or 48 position) for use with 2, 5 and 10 mL reactor vials. Other reactor block options are available including heating block kits and Tip reactor blocks. An infinitely variable vortexer guarantees an optimal mixing of the reactants.



Syro multi-channel peptide synthesizers are the perfect choice for demanding peptide synthesis applications. Digital syringe pumps enable exact dispensing of all reactants with microliter precision. Optimal mixing of the reactants is provided by a variable speed vortex mixer. This guarantees the best synthesis results in terms of yield and purity while minimizing waste and costs. The modular construction offers the greatest flexibility of reaction vessels and storage containers for amino acids and reagents. Reactor blocks with 12, 24, 48 or 96 positions and reactor vials in 0.4 mL (Tip reactor), 2 ml, 5 mL, 10 mL and 20 mL sizes are are available, enabling the parallel synthesis of peptides in a scale range from 1–600 μmol in each reactor vial. The Syro I system is configured with one reactor block and can be configured with one 96 position Tip reactor block (optional accessory).

Simple & Flexible

Syro XP software controls the instrument functions and calculates all amounts and volumes of amino acids and reagents required. Each cycle of the synthesis can receive a completely different protocol. This flexibility allows not only single or multiple couplings, but also complete freedom in the choice of coupling strategies within any synthesis cycle.

Pre-activation of the amino acids can be performed for all the synthesis cycles or just for individual ones. The amino acids can be activated in parallel or individually directly prior to their distribution.

The Tip Synthesis option is designed for applications that require large numbers of peptides in small quantities (1–5 μmol). Each Tip Synthesis Module can be used to synthesize up to 96 peptides at a time. Each peptide is synthesized in a 0.4 ml tip with PE frit where accurate dispensing of reagents is essential. The Syro I system can accommodate 1 Tip Synthesis Module, and the Syro II system can accommodate 3–6 modules, allowing up to 576 peptides to be made at the same time.

Syro I is equipped with one type-U reactor block that can accept 2, 5 and 10 ml reactors. An infinitely variable vortexer guarantees an optimal mixing of the reactants.

Digital injection pumps enable dosing with microliter precision and user-friendly software allows all technical possibilities of the robot to be easily implemented.

The modular construction offers great flexibility with respect to the number and size of the storage and reaction containers. Optionally, all storage containers for reagents and reactors can be equipped with the capability to work under inert gas.


  • Single robotic arm
  • Customizable reactor blocks with 24 or 48 positions
  • Disposable amino acid containers
  • Variable scale from 1–600 μmol
  • Off-line cleavage

Optional Accessories

  • Inert gas option for reagent containers, amino acid rack and reactor vials
  • Inert gas cover plates
  • Disposable polypropylene reactor vials
  • Cleavage and Transfer Workstation
  • Standalone vortex mixer for cleavage unit
  • Reactor blocks
  • Tip Synthesis Module


AUTOMATION       Single robotic arm
DIMENSIONS       Footprint (W x D x H): 56 cm x 70 cm x 91 cm
EQUIPMENT       Includes desktop PC, flat panel monitor, printer, and Syro XP software
ROBOT POWER REQUIREMENTS (MAX. 250 W)       EU:230 V~, 50 Hz (1.5 A) USA: 120 V~, 60 Hz (2.5 A) Japan: 100 V~, 50/60 Hz (3.0 A)
VACUUM PUMP POWER REQUIREMENTS       EU: 230 V~, 50/60 Hz (1.4 A) USA: 120 V~, 60 Hz (3 A) Japan: 100–115 V~, 50/60 Hz (3.8 A)
WEIGHT       60 kg (132 lbs.)
LIQUID HANDLING       Two 5 mL digital syringe pumps
MIXING       Vortex mixer for reactor block
REACTOR BLOCK (STANDARD)       One U-type reactor block for 2, 5 and 10 mL reactor vials. Choice of either 24 or 48 positions.
AMINO ACID RACK       40 x 50 mL
REAGENT BOTTLE RACK       2 x 500 mL, 3 x 200 mL
WASTE BOTTLE     1 x 10 liter Nalgene bottle

Syro I and II at a glance