Syro II

Fully Automated Parallel Peptide Synthesizer

Syro II is a fully automated multi-channel peptide synthesizer equipped with a two arm pipetting robot for faster washing and dispensing of reagents. The standard system is configured with two reactor blocks with other reactor block options available including heating block kits and Tip reactor blocks. This is the system of choice for those requiring the highest peptide synthesis throughput.



Syro multi-channel peptide synthesizers are the perfect choice for demanding peptide synthesis applications. Digital syringe pumps enable exact dispensing of all reactants with microliter precision. Optimal mixing of the reactants is provided by a variable speed vortex mixer. This guarantees the best synthesis results in terms of yield and purity while minimizing waste and costs. The modular construction offers the greatest flexibility of reaction vessels and storage containers for amino acids and reagents. Reactor blocks with 18, 24, 48 or 96 positions and reactor vials in 0.4 mL (Tip reactor), 2 mL, 5 mL, 10 mL and 20 mL sizes are are available, enabling parallel synthesis of peptides in a scale range from 1–600 μmol in each reactor vial. The Syro II system is configured with two reactor blocks and can be configured with three or six 96 position Tip reactor blocks (optional accessory).

Simple & Flexible

Syro XP software controls the instrument functions and calculates all amounts and volumes of amino acids and reagents required. Each cycle of the synthesis can receive a completely different protocol. This flexibility allows not only single or multiple couplings, but also complete freedom in the choice of coupling strategies within any synthesis cycle.

Pre-activation of the amino acids can be performed for all the synthesis cycles or just for individual ones. The amino acids can be activated in parallel or individually directly prior to their distribution.

The Tip Synthesis option is designed for applications that require large numbers of peptides in small quantities (1–5 μmol). Each Tip Synthesis Module can be used to synthesize up to 96 peptides at a time. Each peptide is synthesized in a 0.4 ml tip with PE frit where accurate dispensing of reagents is essential. The Syro I system can accommodate 1 Tip Synthesis Module, and the Syro II system can accommodate 3–6 modules, allowing up to 576 peptides to be made at the same time.

The left arm is equipped with a pipette tip that is connected to a dosing pump via a tube and a three-way valve. All of the reagents defined on the work area can be sampled by the left arm and delivered to any chosen container on the work area. Additionally, the left arm can take in a solvent from outside the work area via the three-way valve and also deliver it to any reachable container.

The right arm possesses a triple pipetting comb in which every single pipette tip is attached to a dosing pump via a tube and a three-way valve. The pumps take up washing solutions and reagents from storage containers outside of Syro through the valve and the distributor. All wash steps and simultaneous reagent distribution, for example piperidine distribution, can be carried out by the right arm.


  • Dual robotic arms
  • Customizable reactor blocks with 96 positions
  • Disposable amino acid containers
  • Variable scale from 1–600 μmol
  • Off-line cleavage

Optional Accessories

  • Inert gas option for reagent containers, amino acid rack and reactor vials
  • Inert gas cover plates
  • Disposable polypropylene reactor vials
  • Cleavage and Transfer Workstation
  • Standalone vortex mixer for cleavage unit
  • Reactor blocks
  • Tip Synthesis Module


AUTOMATION     Dual robotic arm with a triple pipetting washcomb
DIMENSIONS     Footprint (W x D x H): 82 cm x 70 cm x 91 cm
WEIGHT     85 kg (187 lbs.)
EQUIPMENT     Includes desktop PC, flat panel monitor, printer, and Syro XP software
ROBOT POWER REQUIREMENTS (MAX. 250 W)     EU:230 V~, 50 Hz (1.5 A) USA: 120 V~, 60 Hz (2.5 A) Japan: 100 V~, 50/60 Hz (3.0 A)
VACUUM PUMP POWER REQUIREMENTS     EU: 230 V~, 50/60 Hz (1.4 A) USA: 120 V~, 60 Hz (3 A) Japan: 100–115 V~, 50/60 Hz (3.8 A)
LIQUID HANDLING     Four digital syringe pumps – 1 x 5 mL digital syringe pump for amino acid addition, 3 x 10mL digital syringe pumps for solvent wash and reagent addition.
MIXING     Vortex mixer for two reactor blocks
REACTOR BLOCK (STANDARD)     Two U-type reactor blocks for 2, 5 and 10 mL reactor vials. Choice of either 24 or 48 positions
AMINO ACID RACK     40 x 50 mL
REAGENT BOTTLE RACK     3 x 500 mL, 4 x 200 mL
WASTE BOTTLE      1 x 20 liter Nalgene bottle

Syro I and II at a glance